Fishtown Medicine Library
Emerging Science
Deep dives into the latest papers. What's hype, what's mechanism, and what matters for your health.
Do Antioxidant Supplements Work?
Oxidative stress harms your cells, yet antioxidant supplements mostly fail in trials and sometimes cause harm. Why flooding your cells backfires, and what to do instead, from Fishtown Medicine in Philadelphia.
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Plasmalogens and Brain Aging: What the Evidence Shows
Plasmalogens are brain fats that fall with age and drop further in Alzheimer's. The biology is strong, the supplement evidence is early. A measured read from Fishtown Medicine in Philadelphia.
GLP-1s and Your Brain
A Philadelphia doctor on what emerging research says about GLP-1s and the brain: food noise, 'Ozempic personality,' addiction, mood, and what to watch for.
Bioidentical Hormones & WHI Data
Setting the record straight on hormone replacement therapy. See why the WHI study was misread and what bioidentical estrogen and progesterone really do.
Biological Age Testing
You have two ages: chronological and biological. See why epigenetic methylation clocks are the gold standard for measuring how fast you are aging.
Cold Plunge & Metabolic Reset
The Søberg Principle: why 11 minutes of cold exposure a week may shift your dopamine, brown fat, and metabolic health.
The Metabolic Reset
Why semaglutide and tirzepatide are more than diet drugs. They lower inflammation, dampen addiction circuits, and protect the heart.
Hyperbaric Oxygen & Brain Repair
Can high-pressure oxygen wake up sleeping neurons? See the science of HBOT for stroke recovery, traumatic brain injury, and brain fog.
High Dose Vitamin C: The Pro-Oxidant Switch
At low doses Vitamin C is an antioxidant. At very high IV doses it changes mechanism entirely. See the science of pharmacologic ascorbate.
IV Vitamin Therapy
Is IV hydration and nutrient therapy worth the hype? See the science of bioavailability and when high-dose IVs make clinical sense.
Peptide Therapy: What Patients Should Know
An educational primer on peptide therapy, the FDA-approved options today, and why state medical boards prohibit physician involvement with research- grade peptides.
Rapamycin: Smart Drug or Risky Bet?
Rapamycin extends life in mice. The human picture is messier. A skeptical physician's review of the most hyped drug in longevity medicine.
The 'Oatmeal Test': Why You Need a CGM Even If You Aren't Diabetic
Go beyond HbA1c. Continuous Glucose Monitors (CGM) reveal your unique metabolic response to food. Learn how we use data to fix metabolism.
Metformin for Longevity: The Anti-Aging Drug?
Is metformin a magic pill for aging? See why we do not prescribe it to every patient, particularly athletes, and how we manage the risks.
NAD+ vs. AG1: Separating the Science from the Hype
We dissect NAD+ boosters and greens powders to see what works for longevity. A clinical review from Dr. Ash.
Red Light Therapy: Photosynthesis for Humans
Learn how red light therapy (photobiomodulation) works at the mitochondrial level to boost energy, reduce inflammation, and accelerate recovery. Philadelphia...
Sauna Strategies: The Cardiovascular Mimetic
Why sauna is a "cardiovascular mimetic" that may rival exercise for heart health. The science of heat shock proteins and our 20-at-175 strategy.