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Clinical Guide Library

Precision medicine strategies tuned to your unique biology.

Beta-Blocker vs Benzodiazepine for Situational Anxiety: How the Two Compare
Featured Clinical Treatments and Supplement Guides

Two ways to quiet a moment, and what each one costs

Propranolol blocks the body's adrenaline response. A benzodiazepine sedates the brain. Side by side on speed, duration, side effects, dependence, and what each one does to a performance.

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Are Beta-Blockers Banned in Sports? The WADA Prohibited List Explained
Clinical Treatments and Supplement Guides | Fishtown Medicine

Banned in the sports where they work

Beta-blockers are prohibited under WADA class P1 in a defined set of sports. Which ones, when the ban applies, and how a therapeutic use exemption works.

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CBT-I for Insomnia: The First-Line Treatment That Works Better Than Sleeping Pills
Clinical Treatments and Supplement Guides | Fishtown Medicine

The treatment that outlasts the pill

Every major guideline says to try CBT-I before a sleeping pill. What the five parts are, why sleep restriction is the active ingredient, and who it is wrong for.

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Doxepin for Sleep: The Low Dose Is FDA-Approved and a Different Drug
Clinical Treatments and Supplement Guides | Fishtown Medicine

3mg and 150mg are not the same medicine

At 3mg to 6mg, doxepin is a selective antihistamine approved for sleep maintenance. At antidepressant doses it is a tricyclic with all that implies. The gap is the whole story.

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Gabapentin for Sleep: Why It Is Not a Casual Prescription
Clinical Treatments and Supplement Guides | Fishtown Medicine

The one that increases deep sleep, and the one with a tether

Gabapentin does increase slow-wave sleep. It also carries a breathing warning, a withdrawal syndrome, and enough misuse potential to be scheduled in several states.

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Hydroxyzine for Sleep: Dose, Tolerance, and the Anticholinergic Question
Clinical Treatments and Supplement Guides | Fishtown Medicine

The antihistamine, and the question nobody asks about it

Hydroxyzine sedates through the same pathway as older allergy medicines. What that costs in anticholinergic burden, why tolerance builds fast, and who should avoid it.

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Is Propranolol Addictive? Dependence, Withdrawal, and What the Rebound Is
Clinical Treatments and Supplement Guides | Fishtown Medicine

Not addictive, and still not a pill to stop abruptly

Propranolol causes no euphoria and no dependence, and daily use produces a physiological rebound on abrupt stopping. Why those are different things.

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Propranolol and Alcohol: Why the Combination Drops Your Blood Pressure
Clinical Treatments and Supplement Guides | Fishtown Medicine

The drink and the tablet pull the same direction

Both lower blood pressure and both are often taken before the same events. What the interaction does, how long to leave between them, and what to do if you already have.

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Propranolol and Exercise: What It Does to Your Heart Rate, Zones, and Watch Data
Clinical Treatments and Supplement Guides | Fishtown Medicine

The day your zones stop meaning anything

A beta-blocker caps your heart rate for hours, so training zones, wearable data, and VO2 max estimates all read wrong. How to schedule around it.

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Propranolol Dosage and Timing: How Much, How Long Before, and How Long It Lasts
Clinical Treatments and Supplement Guides | Fishtown Medicine

How much, how early, how long

The three questions people ask together. Dose ranges for situational use, when to take it, how long the effect holds, and why the first dose belongs at home.

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Propranolol for Performance Anxiety: Dose, Timing, Safety, and Who Should Not Take It
Clinical Treatments and Supplement Guides | Fishtown Medicine

Propranolol, from the prescribing side

What propranolol does to adrenaline, the dose and timing people use before an event, the interactions that change the answer, and the conditions that make it unsafe.

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Propranolol Side Effects: What Is Common, What Is Rare, and What Needs Urgent Care
Clinical Treatments and Supplement Guides | Fishtown Medicine

What it feels like, and what to do about it

Most side effects follow directly from the mechanism. Which ones to expect at situational doses, which belong to daily use, and the ones that mean stop now.

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Trazodone for Sleep: Dose, Side Effects, and Why the Guideline Says No
Clinical Treatments and Supplement Guides | Fishtown Medicine

The most-prescribed sleep drug with the least evidence

Low-dose trazodone is one of the most common sleep prescriptions in America. The sleep guideline recommends against it. Both of those are true.

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Who Should Not Take Propranolol: The Full Contraindication List
Clinical Treatments and Supplement Guides | Fishtown Medicine

The answers that make me say no

The conditions, medicines, and situations that rule propranolol out or change the plan, written from the screening side, with the reason each one is on the list.

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Z-Drugs for Insomnia: Ambien, Lunesta, Sonata and the Boxed Warning
Clinical Treatments and Supplement Guides | Fishtown Medicine

The sleeping pills that carry a boxed warning

Zolpidem, eszopiclone and zaleplon work, and they carry an FDA boxed warning for complex sleep behaviors. What that means, who should avoid them, and how they are prescribed here.

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Adult Vaccine Schedule Philadelphia | What You Need by Age
Clinical Treatments and Supplement Guides | Fishtown Medicine

The Adult Vaccine Schedule, by Age

Which vaccines adults need and when, as of 2026: flu each fall, shingles and pneumonia at 50, RSV, tetanus, hepatitis B, and the catch-ups adults miss.

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Travel Medicine Philadelphia | Vaccines and Trip Prep
Clinical Treatments and Supplement Guides | Fishtown Medicine

What to Sort Out Before Your Trip

A trip is booked. What to sort out and when: destination vaccines, malaria pills, the diarrhea plan, the kit. Ideally 4-6 weeks out; 1 week still counts.

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Pennsylvania Medical Marijuana Card | How the Program Works
Clinical Treatments and Supplement Guides | Fishtown Medicine

Pennsylvania's Medical Marijuana Program, Explained

The qualifying conditions, the 4 steps in order, what it costs, which forms are legal, and what the law does and does not protect you from at work.

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Do I Need Antibiotics? Adult Guide to 5 Common Infections
Clinical Treatments and Supplement Guides | Fishtown Medicine

Do I Need Antibiotics?

Sinus infection, bronchitis, cold, sore throat, and UTI. What the criteria are for each, which ones need antibiotics, and what helps otherwise.

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When Blood Pressure Medication Stops Working: What Changes
Clinical Treatments and Supplement Guides | Fishtown Medicine

When a Blood Pressure Medication Stops Working

Why a losartan-to-telmisartan switch is often the next move, where a thiazide-like diuretic fits, and when to look for a cause behind the number.

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Metoprolol Tartrate vs Succinate: Which Form and Why It Changes
Clinical Treatments and Supplement Guides | Fishtown Medicine

Metoprolol: Tartrate vs Succinate

Why the short-acting form is right for finding your dose and the long-acting one is right for staying on it, plus the pill-in-the-pocket approach.

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Heavy Metal Detox: The Science vs. Sauna Myths
Clinical Treatments and Supplement Guides | Fishtown Medicine

Heavy Metal Detox: The Science

Bioaccumulation is real, but most "detox teas" are not. Learn how to safely test for and reduce heavy metals using sauna, binders, and (rarely) chelation.

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Integrative Cancer Care: The Metabolic Adjunct
Clinical Treatments and Supplement Guides | Fishtown Medicine

Integrative Cancer Care

Going beyond the standard of care. Learn how Medicine 3.0 uses metabolic therapies and fasting alongside oncology to support patients through treatment.

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Magnesium Breakthrough: Correcting the "Invisible Deficiency"
Clinical Treatments and Supplement Guides | Fishtown Medicine

Magnesium: The Invisible Deficiency

Why standard magnesium tests miss most deficiencies and how to choose the right form for sleep, brain fog, and anxiety.

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Mindfulness: The Anti-Inflammatory Practice You Can't Prescribe
Clinical Treatments and Supplement Guides | Fishtown Medicine

Mindfulness as a Biological Tool

It is not "woo-woo." Learn the neuroscience of how mindfulness lowers cortisol, calms the amygdala, and reduces inflammation.

Read Article
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